Abstract: Objective: to explore the diagnostic value of gd-eob-dtpa enhanced MRI for liver cancer in the background of liver cirrhosis.Methods: the MRI findings of 20 patients with hepatocellular carcinoma confirmed by pathology were retrospectively analyzed.Results: 25 nodules were found in 20 patients with hepatitis b cirrhosis.A total of 22 nodules were diagnosed as hepatocellular carcinoma by MRI plain scan and classic phase iii dynamic enhancement scan, and the other 3 nodules were diagnosed as RN or DN nodules of cirrhosis.Twenty cases of liver cancer were diagnosed by high-b DWI imaging, and the other five cases were benign lesions.Twenty-five cases of liver cancer were diagnosed by enhanced MRI with gd-eob-dtpa.The diagnostic accuracy of plain MRI and classic phase iii dynamic enhanced MRI, high-b-value DWI imaging, gd-eob-dtpa enhanced MRI for hepatocellular carcinoma was 88%, 80%, and 100%, respectively, with statistically significant differences(P<0.05).ROC curve showed that the sensitivity, specificity and accuracy of gd-eob-dtpa enhanced MRI in the diagnosis of liver cancer were significantly higher than that of plain MRI, classical phase iii dynamic enhancement and high-b-value DWI alone, and the area under the curve(P<0.05).Conclusion: gd-eob-dtpa enhanced MRI can improve the diagnostic efficacy of liver cancer in the context of liver cirrhosis, which is worthy of clinical application.