Abstract: Objective: To investigate the value of multi-slice spiral CT guided percutaneous transforaminal lumbar discectomy. Methods: Eighty patients with lumbar disc herniation were enrolled in this study. All of them underwent single disc intervertebral disc discectomy, all under the guidance of multi-slice spiral CT. Results: Compared with the conventional fluoroscopy, the operation under CT guidance is more convenient, which can predict the puncture site and puncture path angle and depth more accurately, shorten the operation time and reduce the occurrence of intraoperative tissue damage Probability, reduce complications. Conclusion: CT guided percutaneous transforaminal lumbar discectomy is safe and reliable, and can achieve better diagnosis and treatment effect, which can be vigorously promoted in clinic.