鼻咽癌放疗后正常显示脑灰质的容积变化——基于体素的MR形态学研究

Volume Changes in Normal-Appearing Gray Matter for Nasopharyngeal Carcinoma by Using MR Voxel-based Morphometry

摘要: 目的:探讨鼻咽癌患者放疗后全脑灰质体积的改变情况。方法:对20例接受过放射治疗的鼻咽癌患者及16例已确诊而未行放射治疗的鼻咽癌患者,进行全脑高分辨率T1WI扫描,采用基于体素形态测量学(VBM)方法,分析鼻咽癌治疗组与未治疗组脑灰质体积变化的差异。结果:与未治疗组比较,鼻咽癌治疗组双侧颞中回、左侧额上回、左侧枕下叶脑灰质体积显著减少。结论:鼻咽癌放疗后部分脑区脑灰质体积减少,VBM可早期发现常规MRI未显示的异常。

Abstract: Objective: To assess the radiation-induced gray matter (GM) volume differences between nasopharyngeal carcinoma (NPC) patients who had and had not received radiotherapy (RT). Methods: Differences in GM volume between 20 NPC patients after RT and 16 control patients with newly diagnosed but not yet medically treated NPC was assessed by using magnetic resonance imaging voxel-based morphometry (VBM). Results: Patients who had received RT had GM volume decreases in the bilateral middle temporal gyrus, left superior frontal gyrus and left inferior occipital lobular, cluster size >100 voxels. Conclusion: GM volume deficits in bilateral temporal lobes in patients who had received RT. VBM can detect the earlier GM alteration which conventional MR can not detect.