Abstract: Objective: To compare the expression of VEGF and the peak value of CT in 56 patients with esophageal cancer, and to study the correlation between them, and to provide reference for imaging diagnosis and early detection of esophageal cancer. Methods: Before operation, fifty-six cases of patients had an examination by routine and dynamic enhanced CT scan, get the CT scan value and enhance the peak value of each phase lesion. The positive expression of VEGF in esophageal mucosa and esophageal cancer tissues of control group was determined by immunohistochemical technique. Used statistical software SPSS 21.0 to process statistical analysis of all experimental data. Results: Enhancement of VEGF expression is related possibly to occurrence and metastasis of squamous cell carcinoma by lymph-vessel. These results showed that CT enrichment degree was not related to VGEF expression in esophageal mucosa of squamous cell carcinoma, indicating that CT enrichment degree in lesion do not respond directly lymph node metastases of carcinoma. Conclusion: Enhanced expression of VEGF may be a marker of squamous cell carcinoma and lymph node metastasi, The enhancement of the lesion in the CT scan could not reflect the metastasis of the tumor lymph nodes.