Abstract: Objective: To evaluate and forecast the occurrence of obstructive coronary artery disease (CAD) and development through carotid artery atherosclerotic plaque and luminal stenosis degree. Methods: 81 patients who had exarned both with head-and-neck CTA and coronary CTA were retrospectively analyzed, evaluating image quality and the nature of the atherosclerotic plaque, and calculate the degree of stenosis. According to the carotid artery stenosis degree can be divided into two groups: moderate or more narrow and mild stenosis group, and the corresponding coronary artery luminal stenosis degree for independent samples t test between the two groups respectively. Line and according to the patients with head and neck CTA inspection head CT scan results grouping: cerebral infarction group and cerebral infarction, and t test between the two groups. According to the common carotid, internal carotid artery level is above moderate stenosis group and mild stenosis group transient ischemic attack (TIA) of the probability for a chi-square test. Static analysis of 81 cases of patients ECG, angina pectoris, and transient ischemic attack incidence and presence of cerebral infarction and carotid-the relationship between the degree of internal carotid artery stenosis. Results: in 81 cases of simultaneously or successively in the patients with head and neck CTA and coronary CTA, head CT scan of cerebral infarction, coronary artery plaque formation corresponding degree of stenosis, the t test results between the two groups have statistically significant difference (P< 0.05). The corresponding degree of coronary artery stenosis cerebral infarction group than in cerebral infarction group, t test results between the two groups have statistically significant differences (P < 0.05). Of common carotid, internal carotid artery stenosis degree of TIA probability of McNemar test have a statistically significant difference (P < 0.05). In 81 cases with analysis of its static ECG, TIA set of static electrocardiogram ST-T change and rate of angina pectoris occurred was obviously higher than that of the TIA group (P<0.05).Conclusion: carotid, internal carotid artery stenosis degree and the development of coronary atherosclerosis lesions corresponding correlation. There was a moderate or above internal carotid artery stenosis, the incidence of TIA, and the TIA group client static ECG ST-T period of change and the incidence of angina pectoris were higher than without the TIA group.