Abstract: Objective: To explore CT imaging features of chronic severe hepatitis complicated with invasive pulmonary fungal infection and provide the basis for the diagnosis and treatment of patients. Methods: 92 patients with chronic severe hepatitis complicated with invasive pulmonary fungal infection from October 2014 to October 2016 were randomly divided into two groups (n=46). The control group was treated with conventional therapy, and the observation group was treated with fluconazole on the basis of routine treatment. The CT imaging features of the two groups before and after treatment were compared. Results: All 92 patients with chronic severe hepatitis complicated with invasive pulmonary fungal infection, a total of 176 strains of pathogens were cultured. The percentage of Candida species was the highest in the two groups, 44.44% in the control group and 41.05% in the observation group, followed by Aspergillus, the distribution of all pathogens in the two groups was not statistically significant (P 〉 0.05). After treatment, the proportion of nodule, ground glass, grid or line and pleural effusion in the observation group was significantly lower than that in the control group (P 〈 0.05). Of the patients, 42 were aspergillous and 35 were Candida infections. There were significant differences in the type and number of nodules between patients with Candida and Aspergillus infection (P 〈 0.05). Conclusion: It is important to diagnose CT in patients with chronic severe hepatitis complicated with invasive pulmonary fungal infection. Candida and Aspergillus are the main pathogens, and the CT imaging features of patients with different pathogens are different.