Abstract: The existence of multiple waves will reduce the signal to noise ratio of seismic data, and effect quality of seismic data processing and the subsequent geological interpretation accuracy, so the suppression of multiple wave interference is an important work in the processing of seismic data. Author modeled seismic wave field of several typical geological model through using the finite difference method, After NMO correction, then transformed the reflected wave and multiple wave in the t-x domain to the τ-q domain through the method of parabolic Radon transform. Energy convergence is obtained in the τ-q domain, because of the velocity differences between the reflected wave and the multiple wave, the reflection wave and the multiple wave energy were apart from each other in the τ-q domain, so we can get rid of multiple wave energy in the Radon domain and retain the reflected wave information effectively, then reached the suppression of multiple wave effect, improved the signal-to-noise ratio. The suppression of multiple waves were further verified by the results of the parabolic Radon transform of the real seismic data.