Abstract: Objective: To explore the application value of iodine contrast agent with high concentration in the ophthalmic artery angiography in dual source dual energy CT angiography. Methods: From March 2014 to December 2015, 80 patients(160 eyes) with brain CTA were selected in our hospital. 80 patients were randomly divided into observation group and control groups, Judgment and analysis of the two groups of dual energy CT angiography and spiral CT subtraction, the former uses the Bayer 370 mg I/m L contrast agent, the latter uses the GE 350 mg I/m L contrast agent. Results: The ophthalmic artery CT angiography images of all subjects showed clear, full of each vessel filling well. After the measurement, the intracranial segment of the observation group, the optic nerve canal segment, the diameter of the orbital segment and other ocular artery were significantly more than the control group(P<0.05), Diameter(mm) were: 1.26 ±0.16, 1.21 ±0.18, 1.12 ±0.14. The detection rate of plaque in the observation group and the control group were 28.8% and 2.5%, the observation group was significantly higher than that of the control group(P<0.05). Conclusion: Using dual source spiral CT dual energy CT angiography applied in the judgment of the ophthalmic artery disease showed good effect. Can effectively judge the diameter of the ophthalmic artery and plaque situation, so as to guide the treatment.