Abstract: Objective: To investigate CT double phase enhanced scan in the diagnosis of thyroid adenoma and nodular goiter. Methods: A retrospective comparison of 25 cases handled postoperative pathology confirmed thyroid adenoma and nodular goiter patients with CT scan and enhanced scan results, and analyzed. Results: A total of 25 patients took 35 thyroid nodule, 18 thyroid adenoma and nodular goiter 17 pieces. Adenoma group scan CT value of 30~60 HU, nodular goiter group scan CT value of 25~55 HU, both difference is not obvious. Adenoma group enhanced scanning CT value 120~160 HU, nodular goiter set 60~100 HU, CT scan, there were significant differences between the two. Conclusion: CT double phase enhancement of thyroid adenoma and thyroid provide basis for the differential diagnosis of nodular goiter.