Abstract: Objective: To analyze the CT and MRI features of multiple hepatic biliary hamartoma in adult to improve diagnostic level. Methods: Retrospectively analyzed the clinical and imaging features of 12 patients with pathologically confirmed multiple hepatic biliary hamartomas and summarized the imaging features. Results: Plain CT scan showed multiple lesions which were low density, diffuse or scattered in the distribution, unclear boundary, varied shapes, the diameter of the most of lesion was less than 15 mm, no enhancement in contrast enhanced scan. The signal of lesions was lower than that of normal liver parenchyma in the T₁ WI sequence, markedly hyperintensity in T₂ WI sequence which showed clearer. The T₂ WI sequence was better than CT and T₁ WI in finding quantity of the diseases. Most of lesions with no enhancement, a few foci showed nodular enhancement or slightly circular enhancement. MRCP showed intrahepatic multiple type cystic lesion with high signal and with the bile duct is not connected. Conclusion: CT and MRI findings of multiple hepatic biliary hamartoma in adult had a certain characteristic, but still need to be identified with Caroli disease, liver cystic metastases, multiple liver cysts, polycystic liver and other liver cystic lesions.