Abstract: Objective: To analyze the MSCT manifestation of congenital bronchial atresia, in order to improve the diagnosis level of the disease. Methods: Retrospectively analyze the MSCT manifestation of 15 patients with congenital bronchial atresia, scan the chest of all the 15 patients with spiral CT(GE light-speed 64), and transmit the original images to the AW4.4 workstation for Post-processing and reconstruction. Observe the characteristics of the lesion combining with literature review. Results: The change of bronchial mucus plugs appear in all the 15 cases, six cases in left lungs, 9 cases in right lung, the emphysema around plugs occur in 13 cases, two cases didn't affect with emphysema, 11 cases present the following symptoms that the bronchovascular bundles become thinner, the numbers are reduced and the distribution become more sparse. Conclusion: MSCT can contribute high value to the diagnosis of congenital bronchial atresia, it can show the mucous plugs and the typical symptoms of emphysema around, and the position of congenital bronchial atresia can be located by observing the shape of the mucous plug and its relations to the bronchial tubes and blood vessels through reformation of post-possessing MPR and MIP images, combining with slice images.