Abstract: Objective: To compare and study the diagnosis value of ultrasound and CT in benign and malignant of thyroid nodules, and improve the diagnosis of benign and malignant thyroid nodules accuracy. Methods: A retrospective analysis of the complete medical records from January 2011 to December 2014 in our hospital 120 cases of thyroid nodules in patients was made, and all patients within two weeks had carried ultrasound and CT examination and retained a complete image inspection results, and surgery value evaluation after all confirmed by pathology ultrasound and CT in the diagnosis of benign and malignant thyroid nodules was compared. Results: The sensitivity, specificity and diagnostic accuracy of ultrasound combined with CT was 83.17%, 93.06%, 92.77% respectively, which was significantly higher than the ultrasound and CT, the rates of misdiagnosis and missed diagnosis rate was 9.03%, 15.62% respectively, which was significantly lower than the ultrasound and CT(P<0.05). Conclusion: Ultrasound should be the preferred method of diagnosis of benign and malignant thyroid nodules, but ultrasound and CT diagnostic also have advantages and disadvantages, the combination of ultrasound and CT should thyroid nodules qualitative to improve the diagnosis of benign and malignant thyroid nodules accuracy.