Abstract: Objective: With digital subtraction angiography(DSA) as the gold standard, comparative analysis of multi slice spiral CT coronary angiography(CTA) in the evaluation of coronary artery stenosis of the accuracy and sensitivity of CTA for the clinical value of the examination of coronary artery stenosis. Methods: 78 cases of patients with known or suspected coronary heart disease were selected who diagnosed in our hospital from April 2014 to April 2015, the CTA inspection, and check in a week before and after the adept DSA examination, comparing with the results of CTA and DSA examination analysis, at the same time the pathological changes of lumen stenosis degree and the detection sensitivity and specificity of the comparison. Results: A total of 78 patients, 580 vessels, CTA found 440 coronary artery stenosis; DSA found 446 coronary artery stenosis. On the basis of DSA, CTA check the accuracy of diagnosis of above moderate coronary artery stenosis was 94.96%. CTA in the left main, left anterior descending, left circumflex branch and right coronary artery four specific distribution area and distribution of DSA examination result has high consistency. CTA inspection caused by calcification plaques in the conformity degree of luminal stenosis of 88.20%, due to non calcified plaque conformity degree of luminal stenosis was 90.31%. Conclusion: Multi slice spiral CT coronary angiography can clearly display the coronary vessel wall thickening and stenosis of the arterial wall plaque and calcification of advantage, is an ideal on the diagnosis of coronary artery disease in non-invasive detection method.