Abstract: Objective: To investigate the effect of sFRP1-overexpression on gastric cancer cell line SGC-7901 and gastric cancer imaging. Methods: sFRP1 expression vector and empty vector were transfected into SGC-7901 cells to obtain stable clones(SGC-7901/sFRP1 and SGC-7901/vector). MTT assays were exploited for cell proliferation(in vitro). Peritoneal implantation and lung metastasis models were established by injecting in peritoneal cavity or caudal vein respectively(in vivo), respectively. PET/CT and spectral CT were utilized for tumor imaging. Then all tumors were dissected and conducted with TUNEL and Immunohistochemistry demonstrating apoptosis, proliferation and MVD. Results: TUNEL and Immunohistochemistry showed that SGC-7901/ sFRP1 had higher relative growth rate, less apoptosis, more proliferation and MVD than that of SGC-7901/vector. Tumors induced with SGC-7901/ sFRP1 showed positive results in PET/CT and spectral CT. Conclusion: SFRP1 up-regulation leads to tumorigenesis in vitro and vivo, contributing to the positive performance in PET/CT and spectral CT.