Meta Analysis of Adenosine Antagonists in the Prevention of Contrast Induced Nephropathy

Objective:Evaluation of adenosine antagonists in the prevention of contrast induced nephropathy by Meta analysis. Methods:To search the relevant literature of adenosine antagonists in the prevention of contrast induced nephropathy, extract the data that meet the inclusion criteria, and use Revman 5.0 software for statistical analysis. Results:In this study, 11 randomized controlled trials were included for Meta analysis. There were 1063 patients in total, 526 in the adenosine antagonist group and 537 in the control group. The incidence of CIN in the adenosine antagonist group was significantly lower than that in the control group(RR=0.61, 95% CI:0.42~0.91; P=0.01). The difference was statistically significant(RR=0.61, 95% CI:0.42~0.91; P=0.01).There was no significant difference between the two groups(P=0.46). When the dose of adenosine antagonist was more than 400 mg, the incidence of CIN in the adenosine antagonist group was significantly lower than that in the control group(RR=0.45, 95% CI:0.22~0.89; P=0.02). When the dose of contrast agent was more than 100 ml, the incidence of CIN in the adenosine antagonist group was significantly lower than that in the control group Meaning(RR=0.49, 95% CI:0.33~0.75; P=0.001). Conclusion:adenosine antagonists can reduce the risk of CIN in patients after iodine contrast agent operation. When the dose of adenosine antagonist is more than 400 mg and the dose of contrast agent is more than 100 ml, adenosine antagonist tends to show better CIN prevention effect. The above results need more large samples and multicenter control tests to verify.