A Comparative Study of Non-contrast Cardiac CT and Coronary CT Angiography in Quantitative Analysis of Epicardial Fat Volume
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Abstract
Objective: To compare non-contrast cardiac CT (NCT) and coronary CT angiography (coronary CTA) for quantitative analysis of epicardial fat volume (EFV) in coronary artery disease cohort. Method: Forty patients underwent retrospective NCT and coronary CTA with ECG-gated. Epicardial boundaries were traced by 2 experienced radiologists (operator 1 and operators 2). EFV was calculated by Autocontour software (AW4.7 workstation, GE). Linear Regression, Bland-Altman method, Coefficient of Repeatability (CR) and Intra Class Correlation (ICC) were computed to analyze the inter-observer variability. Result: There was no significant difference (P>0.05) between NCT (99.43±43.78cm3) and coronary CTA (93.66±48.49cm3) in mean EFV values. For operator 1, CR errors were 10.01cm3 (NCT) and 7.83cm3 (coronary CTA), respectively. For operator 2, CR errors were 11.05 cm3 (NCT) and 7.58cm3(coronary CTA), respectively. ICC values >0.96 were obtained in all cases. CR values were 8.05 cm3 for NCT and 7.13cm3 for CTA. Conclusion: Both NCT and coronary CTA can be used to computer-assist measurements of EFV with ECG-gated.
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