Abstract: Objective: To explore the feasibility of low-dose scanning for COVID-19 patients by using the method of high-pitch combined with ASIR, and compare the diffrence of radiation dose and image quality. Methods: 91 patients diagnosed with COVID-19 in our hospital were collected as the low-dose group while 91 cases of undiagnosed COVID-19 patients who were screened for COVID-19 in our hospital during the same period were selected as the conventional dose group. High-pitch combined with ASIR was performed on the low-dose group while conventional dose group was scanned by common pitch and reconstructed by FBP. In order to compare the differnce of the image quality and radiation dose between the two groups, we recorded the radiation dose and performed subjective and objective evaluation of image quality of the two groups.Results: There was statistical differences in radiation dose between the two groups, and the radiation dose of the low-dose group was significantly lower than that of the conventional dose group (the ED was reduced by about 52%). There was no statistical difference in the image quality scores between the two groups; There was no statistical difference in the objective evaluation of images between the two groups . Conclusion: Low dose scanning with high-pitch combined with ASIR for COVID-19 patients can evidently reduce the radiation dose without significant decrease in image quality.