Abstract: In order to improve the efficiency of passenger security inspection at domestic airport, reduce the working strength of security personnel, this paper takes the civil aviation passenger hand luggage check security intelligent process as the research direction, presents a new process of intelligent passenger hand luggage security inspection based on CT security inspection technology, and practices the feasibility of the security inspection process at airport. It fills the gap in the research on the application of CT security screening technology for passenger security screening channels at domestic airport. During the trial operation, the intelligent security inspection channel effectively guarantees the travel of civil aviation passengers, no acts of unlawful interference on the flight occurred. Practice shows that the intelligent passenger hand luggage security mode based on CT security equipment proposed in this paper is feasible. This mode has promoted the quality and efficiency of civil aviation security work.