Abstract: Objective: To analyze the chest and abdominal CT findings and diagnosis of giant lymph cell hyperplasia. Methods: 60 cases of giant lymph cell hyperplasia patients who were collected from January 2000 to September 2014 were selected by random sampling method, all patients were plain and enhanced by Siemens 16-slice CT scan, then the chest and abdominal CT findings and diagnosis of the patients were analyzed. Results: 15 cases of patients were with low or slightly low density, 10 cases were lack of uniform density. Under normal circumstances, the mass had a more uniform density, retroperitoneal tumor and part were lack of uniform density changes; retroperitoneal mass part of a sheet had high-density exists in the center, there was no significant enhancement to strengthen presence in the central, and thoracic and abdominal tumors were significantly strengthen, partly inhomogeneous enhancement; tumor location, size, shape and edge enhancement pattern were direct signs and pressure near the organ case were its indirect signs. Conclusion: Giant lymph cell hyperplasia has a higher rate of misdiagnosis of the chest and abdomen, and enhance scan lesions are significantly enhanced, the degree of enhancement in the thoracic and abdominal aorta are almost simultaneous, the delay continued moderate enhancement, it has very important clinical significance in the diagnosis of giant cell hyperplasia.