Abstract: Purpose: To discuss the basic principle and management methods of decreasing the side-effect of contrast media in CT enhancement scan. Materials and methods: To select two different types contrast and give preventive medicine. eg.Dexamethasone. in 1800 cases CT enhancement scan. To sort, summary and sum-up tile side-effect of contrast media and bring forward concretely management. Result: General rate of side-effect of application ionic-contrast is 5.04%; Generant rate of side-effect of application non-ionic-contrast is 0.9%. Conclusion: It can obviously dicrease side-effect arte and fatal rate of contrast media by resoluble selecting contrast. strictly choosing high risk people. giving preventive medicine and possessing self-contained salvage methods.