Abstract: Objective: Analyze the imaging characteristics of 64-slice spiral CT in benign and malignant ileocecal lesions and the diagnostic value of post-processing techniques.Methods: 53 cases of ileocecal lesions confirmed by operation and pathology were collected.All cases underwent CT plain scan and enhanced scan.The imaging characteristics of benign and malignant ileocecal lesions were analyzed and the diagnostic effects of original axial image and post-processing image were compared.Results: The accuracy of localization and qualitative diagnosis of original axial images combined with MPR/CPR was higher than that of original axial images, and the difference was statistically significant(P=0.03;P=0.04).MPR and CPR can clearly and completely display the relationship between internal and external structures of ileocecal lesions and adjacent organs, and improve the accuracy of diagnosis of ileocecal lesions.Conclusion: 64-slice spiral CT can display ileocecal lesions accurately and intuitively.The combination of original axial images with MPR/CPR images can improve the diagnostic accuracy of ileocecal lesions.