Abstract: Objective: To explore the Multi-slice CT(MSCT) manifestations and pathological basis of ground-glass nodules of lung adenocarcinomas, so as to improve the accuracy of the diagnosis of benign and malignant diseases. Methods: the CT data of 21 ground-glass nodules(GGNs) lesions proved to be lung adenocarcinoma by pathology were analyzed retrospectively, and included analysis of tumor size, nature, interface of tumor and lung,edge, vacuole sign, pleural indentation sign, bronchi and blood vessels through the tumor imaging features. The pathological findings were divided into two groups:preinvasion lesions and invasive lesions, and the CT features of the two groups were compared. Results: preinvasive lesions were 14, of which 13 were smaller than 2.0 cm in length-diameter, 10 were pure ground-glass nodules(p GGNs), 9 interface of tumor and lung were clear and smooth, 8 edges appeared lobular sign and 3 edges showed spicule sign; Invasive lesions were 7, of which 4 length-diameter were greater than 2.0 cm, 5 were mixed ground-glass nodules(m GGNs), 7 interface of tumor and lung were clear and coarse, 6 edges showed lobulation, 6 edges burred spiculation, 4 edge display spinous protuberance; In addition, vacuole sign, pleural indentation sign, bronchi and blood vessels through the tumor in walking and morphologic changes are more common in the invasve lesions. Conclusion: MSCT showed ground-glass nodules of lung cancer have certain characteristics. The probability of invasive lesions is obviously increased when GGNs have larger size, a mixed density, clear and coarse interface of tumor and lung, or when the CT signs, such as deep vacuole sign, lobular sign, spicule sign, spinous protuberant sign, the abnormal changes of bronchi and blood vessels through the tumor.