Abstract: Objective: To analyze the application value of CT scan and enhanced scan in the differential diagnosis of hepatic angiosarcoma (PHA) and hemangioma (CHH). Methods: The CT imaging data of 8 patients with pathologically confirmed PHA and 30 patients with pathologically confirmed CHH were collected. All patients underwent CT plain scan and enhanced scan after admission. The imaging characteristics of hepatic angiosarcoma and hemangioma and the diagnostic value of CT were analyzed. Results: The proportion of uneven density in PHA nodules scanned by CT was higher than that in CHH nodules (P < 0.05); The non-peripheral rate of enhanced PHA nodules was higher than that of CHH (P < 0.05); The ratio of PHA nodules with peritumoral venous shunt was higher than that of CHH, and the ratio of unclear boundaries was higher than that in CHH nodules (P < 0.05), while the enhancement pattern, delayed enhancement characteristics and CT value showed no significant differences (P > 0.05). Conclusion: PHA is characterized by gradual central patchy enhancement, non-peripheral enhancement, and high ratio of arteriovenous shunt while CT of CHH is characterized by peripheral enhancement and low ratio of arteriovenous shunt.