Abstract: Objective: To explore the value of dual source computed tomography angiography in the diagnosis lumen stenosis of intermediate coronary lesions. Methods: DSCTA were performed in 2670 patients, among which 158 patients underwent both DSCTA and CAG within two weeks. And 41 cases were judged to be intermediate coronary lesions via IVUS. The results of DSCTA were compared with that of IVUS. Results: 41 segments of coronary artery in 33 patients (14 males, 19 females, mean age 65.8 years) were analyzed. There were no statistical differences (P > 0.05) compared with the result of Minimal Lumen Area (MLA) and Plaque Burden (PB) obtained by two methods. Regarding IVUS as the gold standard and MLA for 4mm2 as the critical value, the sensitivity, specificity, PPV and NPV of DSCTA were 69.2%, 92.9%, 81.8%, 86.7%, respectively. Conclusions: DSCTA, as a noninvasive and economic coronary artery examination, can accurately assess the degree of luminal stenosis, higher value to the diagnosis of non-pathological coronary stenosis, reducing unnecessary CAG and IVUS examination.